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GSK414 not just blocked Package signaling, but also directed the kinase for lysosomal degradation, an unusual influence of an antagonist. KIRA6, However, possibly by means of aggressive binding safeguarded KIT from GSK414-mediated degradation. The two inhibitors compromised the viability of cells that count on Package signaling for survival. Our information spotlight KIT like a shared target of seemingly unrelated UPR modulators and exhibit a pharmacological method to aid KIT degradation by a kinase inhibitor.
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